Nutritional supplements to treat glaucoma is gaining more evidence as a tool to fight against vision loss from this irreversible disease. Glaucoma is a degeneration of the optic nerve associated with elevate eye pressure. The primary approach to manage glaucoma is reduction of eye pressure through eye drops, laser procedures, and surgery. Lowering the eye pressure has been shown to slow down the disease progression, but it is known that vision loss continues even when the eye pressure is reduced to low levels. While reduction of eye pressure reduces the stress on the optic nerve, fortifying the optic nerve’s ability to withstand these stresses is an area of unmet potential for treatment. These interventions are referred to as neuroprotection. 

     One of the key challenges in glaucoma is oxidative stress, which damages retinal ganglion cells and contributes to nerve degeneration. Nicotinamide and pyruvate have shown potential in supporting cellular health and energy production within the optic nerve, helping to slow the progression of the disease.